Dear writer,
I want the essay describing and explaining the pre-clinical trials for drug development.

i want you please to use ICH (International Conference on Harmonisation of Technical Requirements for Registration for Pharmaceuticals for Human Use) guidelines and other scientific articles and journals please.

i want the essay explaining the process and what tests would be used for carcinogenicity tests, organ toxicity, biochemical dysregulation and which species of animals would be involved. and how it is possible to minimize time and increasing effecacy of results and drugs.

please make the structure of the essay as the following:
1 introduction ( include the references in text please )
2 main body
3 conclusion

Thank you,